Clinical Studies

First to Market
Patent Pending
Clinically Validated 
Targets dog oral-health

Our COHP is research-backed offering clear consumer benefits

COHP has been clinically-validated across the three key oral health endpoints that consumers care about most:
  • Bad breath & bad breath compounds (VSCs)
  • Oral biofilms, plaque, and tartar, and
  • The oral microbiome.
Now backed by THREE independent clinical trials, with a fourth on the way, our COHP is the most clinically-validated oral health postbiotic on the market.

Three Independent Clinical Trials

The details surrounding the studies completed are:
1
Study 1
7-Day Microbial Reduction Study
In a double-blind, placebo-controlled, randomized clinical study with ten dogs over seven days, COHP substantially reduced the unwanted microbes that cause bad breath and produce oral biofilms.
2
Study 2
14-Day Microbiome Health Study
In a double-blind, placebo-controlled, randomized clinical study with 24 dogs over 14 days, COHP substantially lowered the compounds responsible for bad breath compared to the placebo and was shown to promote a healthy oral microbiome (by reducing the abundance of taxa known to form biofilms and cause periodontal disease).
3
Study 3
14-Day Low-Dose Efficacy Study
In a double-blind, placebo-controlled, randomized clinical study with 24 dogs over 14 days, a lower dose of COHP substantially reduced bad breath in dogs (as measured by VSC levels and human perception).

All three studies are in the peer review process

ALL THREE STUDIES ARE IN THE PEER REVIEW PROCESS

Research-Backed Benefits of COHP

Benefit Category
Clinical Results

Benefit Category

1
Bad breath and bad breath compounds (VSCs)

Clinical Results

  • Clinically proven to lower bad breath compounds 26% more from baseline compared to placebo
  • Clinically shown to significantly reduce bad breath compounds after only 7 dayst*
  • Clinically proven to reduce the unwanted microbes responsible for bad breath
  • Reduces bad breath compounds by an average of 85% in vitro

Benefit Category

2
Oral biofilms, plaque, and tartar

Clinical Results

  • Clinically proven to reduce the unwanted microbes that generate biofilms and plaque in just 7 days
  • Disrupts oral biofilms by an average of 98% in vitro (vastly superior performance compared to other commonly-used oral health ingredients including zinc, brown algae, spirulina, and zeolites)fft

Benefit Category

3
Oral microbiome

Clinical Results

  • Clinically shown to reduce P. cangingivalis, a microbe closely linked to periodontal disease
  • Clinically shown to promote a healthy oral microbiome (as evidenced by reducing unwanted taxa and increasing species evenness)

Additional Active Ingredients

Doggie Dental also has other core ingredients that have been clinically proven to promote oral health in pets:

Kale
Natural source of essential nutrients
SMPH
Specialized mineral compound
Neem Leaf
Traditional oral health support